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KMID : 0364020160490040280
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Korean Journal of Thoracic and Cardiovascular Surgery
2016 Volume.49 No. 4 p.280 ~ p.286
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Extracorporeal Life Support in Patients with Hematologic Malignancies: A Single Center Experience
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Choi Kuk-Bin
Kim Hwan-Wook
Jo Keon-Hyon
Kim Do-Yeon
Choi Hang-Jun
Hong Seok-Beom
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Abstract
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Background: Extracorporeal life support (ECLS) in patients with hematologic malignancies is considered to have a poor prognosis. However, to date, there is only one case series reported in the literature. In this study, we compared the in-hospital survival of ECLS in patients with and without hematologic malignancies.
Methods: We reviewed a total of 66 patients who underwent ECLS for treatment of acute respiratory failure from January 2012 to December 2014. Of these patients, 22 (32%) were diagnosed with hematologic malignancies, and 13 (59%) underwent stem cell transplantation before ECLS.
Results: The in-hospital survival rate of patients with hematologic malignancies was 5% (1/22), while that of patients without malignancies was 26% (12/46). The number of platelet transfusions was significantly higher in patients with hematologic malignancies (9.69±7.55 vs. 3.12±3.42 units/day). Multivariate analysis showed that the presence of hematologic malignancies was a significant negative predictor of survival to discharge (odds ratio, 0.07; 95% confidence interval, 0.01?0.79); p=0.031).
Conclusion: ECLS in patients with hematologic malignancies had a lower in-hospital survival rate, compared to patients without hematologic malignancies.
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KEYWORD
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Extracorporeal membrane oxygenation, Acute respiratory distress syndrome (ARDS), Hematology
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